Presymptomatic diagnosis of hereditary breast cancer
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The Impact of Presymptomatic Molecular Testing in Hereditary Cancers
Genetic factors are likely to be the primary determinants in around 5–10% of cancer patients. Over the last decade the identification of some of these cancer susceptibility genes has revolutionised our understanding of cancer in general. In addition, it has allowed us to improve our management of patients in those families with a genetic predisposition by offering presymptomatic testing and hen...
متن کاملGenetic counseling in hereditary nonpolyposis colorectal cancer.
Recent identification of gene mutations responsible for hereditary nonpolyposis colorectal cancer (HNPCC) has made possible the presymptomatic diagnosis of at-risk family members. If DNA testing shows that a family member is a gene carrier, that individual's lifetime cancer risk is approximately 90%. If the test is negative, the family member's cancer risk drops to that of the general populatio...
متن کاملGene assembling: a new approach in molecular diagnosis of hereditary breast cancer
Abstract Background: Many disease susceptibility genes are large and consist of many exons in which point mutations are scattered throughout. Scanning each exon individually represents a tedious task which can be time consuming and expensive. There has been increasing demand for rapid and accurate methods for full scanning of unknown point mutations in large multi-exon genes. Gene Assembling i...
متن کاملWomen with hereditary breast cancer predispositions should avoid using their smartphones, tablets and laptops at night
Breast cancer is the most common malignancy among women, both in the developed and developing countries. Women with mutations in the BRCA1 and BRCA2 genes have an increased risk of breast and ovarian cancers. Recent studies show that short-wavelength visible light disturb the secretion of melatonin and causes circadian rhythm disruption. We have previously studied the health effects of exposure...
متن کاملشناسایی جهش های جدید در اگزون 11 ژنBRCA1 در بیماران مبتلا به سرطان پستان ارثی
Introduction: Breast cancer is the most common malignancy in women worldwide. BRCA1 is a tumor suppressor gene that is involved in DNA-damage repair. One of the significant risk factors of breast cancer is the family history. BRCA1 gene consists of 24 exons that encode a protein with 1863 amino acids. Exon 11 is the largest exons and most of the disease-linked mutations have been found in it. I...
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تاریخ انتشار 2002